Prediction of sulfamerazine and sulfamethazine solubility in some cosolvent mixtures using non-ideal solution models

نویسندگان

چکیده

Introduction: Experimental Solubilities of sulfamerazine (SMR) and sulfamethazine (SMT) in some (methanol + water), (ethanol water) (1-propanol cosolvent mixtures were collected from the literature at five temperatures 293.15 to 313.15 K. Methodology: The results analyzed with van’t Hoff, Apelblat modified, Buchowski-Ksiazaczak λh, Hoff-Yaws model, twoparameter Weibull function model. It was determined that models best describe solubility these sulfonamides (alcohol thevan’t Hoff models, obtaining correlation indices greater than 0.99 all cases. Results: obtained Modified equation presents ahigh index for SMR SMT mixtures, followed by model a high fit estimated data respect theoretical ones. According two parameter co-solvent shows important deviations ideality, which is consistent literature. are discussed terms solute-solvent interactions occur this system.

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ژورنال

عنوان ژورنال: Revista Colombiana de Ciencias Químico - Farmacéuticas

سال: 2021

ISSN: ['0034-7418', '1909-6356']

DOI: https://doi.org/10.15446/rcciquifa.v50n1.95463